OpenCRISPR is a set of free and open gene editing systems designed by Profluent Bio. The OpenCRISPR-1 protein maintains the prototypical architecture of a Type II Cas9 nuclease but is hundreds of mutations away from SpCas9 or any other known natural CRISPR-associated protein. You can view OpenCRISPR-1 as a drop-in replacement for many protocols that need a cas9-like protein with an NGG PAM and you can even use it with canonical SpCas9 gRNAs. OpenCRISPR-1 can be fused in a deactivated or nickase format for next generation gene editing techniques like base, prime, or epigenome editing.

Claudine is an AI agent designed to reason and act autonomously, leveraging the Anthropic API, Unix command line tools, HTTP, local hard drive data, and internet data. It can administer computers, analyze files, implement features in source code, create new tools, and gather contextual information from the internet. Users can easily add specialized tools. Claudine serves as a blueprint for implementing complex autonomous systems, with potential for customization based on organization-specific needs. The tool is based on the anthropic-kotlin-sdk and aims to evolve into a versatile command line tool similar to 'git', enabling branching sessions for different tasks.

MediaAI is a repository containing lectures and materials for Aalto University's AI for Media, Art & Design course. The course is a hands-on, project-based crash course focusing on deep learning and AI techniques for artists and designers. It covers common AI algorithms & tools, their applications in art, media, and design, and provides hands-on practice in designing, implementing, and using these tools. The course includes lectures, exercises, and a final project based on students' interests. Students can complete the course without programming by creatively utilizing existing tools like ChatGPT and DALL-E. The course emphasizes collaboration, peer-to-peer tutoring, and project-based learning. It covers topics such as text generation, image generation, optimization, and game AI.

AutoGroq is a revolutionary tool that dynamically generates tailored teams of AI agents based on project requirements, eliminating manual configuration. It enables users to effortlessly tackle questions, problems, and projects by creating expert agents, workflows, and skillsets with ease and efficiency. With features like natural conversation flow, code snippet extraction, and support for multiple language models, AutoGroq offers a seamless and intuitive AI assistant experience for developers and users.

Clipboard Conqueror is a multi-platform omnipresent copilot alternative. Currently requiring a kobold united or openAI compatible back end, this software brings powerful LLM based tools to any text field, the universal copilot you deserve. It simply works anywhere. No need to sign in, no required key. Provided you are using local AI, CC is a data secure alternative integration provided you trust whatever backend you use. *Special thank you to the creators of KoboldAi, KoboldCPP, llamma, openAi, and the communities that made all this possible to figure out.

This practical free hands-on course focuses on Large Language models and their applications, providing a hands-on experience using models from OpenAI and the Hugging Face library. The course is divided into three major sections: Techniques and Libraries, Projects, and Enterprise Solutions. It covers topics such as Chatbots, Code Generation, Vector databases, LangChain, Fine Tuning, PEFT Fine Tuning, Soft Prompt tuning, LoRA, QLoRA, Evaluate Models, Knowledge Distillation, and more. Each section contains chapters with lessons supported by notebooks and articles. The course aims to help users build projects and explore enterprise solutions using Large Language Models.

Your Smart Second Brain is a free and open-source Obsidian plugin that serves as your personal assistant, powered by large language models like ChatGPT or Llama2. It can directly access and process your notes, eliminating the need for manual prompt editing, and it can operate completely offline, ensuring your data remains private and secure.

Build-your-own-AI-Assistant-Solution-Accelerator is a pre-release and preview solution that helps users create their own AI assistants. It leverages Azure Open AI Service, Azure AI Search, and Microsoft Fabric to identify, summarize, and categorize unstructured information. Users can easily find relevant articles and grants, generate grant applications, and export them as PDF or Word documents. The solution accelerator provides reusable architecture and code snippets for building AI assistants with enterprise data. It is designed for researchers looking to explore flu vaccine studies and grants to accelerate grant proposal submissions.

Motleycrew is an ultimate framework for building multi-agent AI systems, allowing users to mix and match AI agents and tools from popular frameworks, design advanced workflows, and leverage dynamic knowledge graphs with simplicity and elegance. It acts as a conductor orchestrating a symphony of AI agents and tools, providing building blocks for creating AI systems and enabling users to focus on high-level design while taking care of the rest. The framework offers integration with various tools, flexibility in providing agents with tools or other agents, advanced flow design capabilities, and built-in observability and caching features.

LocalChat is a simple, easy-to-set-up, and open-source local AI chat tool that allows users to interact with generative language models on their own computers without transmitting data to a cloud server. It provides a chat-like interface for users to experience ChatGPT-like behavior locally, ensuring GDPR compliance and data privacy. Users can download LocalChat for macOS, Windows, or Linux to chat with open-weight generative language models.

PythonDataScienceFullThrottle is a comprehensive repository containing various Python scripts, libraries, and tools for data science enthusiasts. It includes a wide range of functionalities such as data preprocessing, visualization, machine learning algorithms, and statistical analysis. The repository aims to provide a one-stop solution for individuals looking to dive deep into the world of data science using Python.

FoundationaLLM is a platform designed for deploying, scaling, securing, and governing generative AI in enterprises. It allows users to create AI agents grounded in enterprise data, integrate REST APIs, experiment with various large language models, centrally manage AI agents and their assets, deploy scalable vectorization data pipelines, enable non-developer users to create their own AI agents, control access with role-based access controls, and harness capabilities from Azure AI and Azure OpenAI. The platform simplifies integration with enterprise data sources, provides fine-grain security controls, scalability, extensibility, and addresses the challenges of delivering enterprise copilots or AI agents.

The Azure-Analytics-and-AI-Engagement repository provides packaged Industry Scenario DREAM Demos with ARM templates (Containing a demo web application, Power BI reports, Synapse resources, AML Notebooks etc.) that can be deployed in a customer’s subscription using the CAPE tool within a matter of few hours. Partners can also deploy DREAM Demos in their own subscriptions using DPoC.

SkyEye is an AI-powered Ground Controlled Intercept (GCI) bot designed for the flight simulator Digital Combat Simulator (DCS). It serves as an advanced replacement for the in-game E-2, E-3, and A-50 AI aircraft, offering modern voice recognition, natural-sounding voices, real-world brevity and procedures, a wide range of commands, and intelligent battlespace monitoring. The tool uses Speech-To-Text and Text-To-Speech technology, can run locally or on a cloud server, and is production-ready software used by various DCS communities.

FoundationaLLM is a platform designed for deploying, scaling, securing, and governing generative AI in enterprises. It allows users to create AI agents grounded in enterprise data, integrate REST APIs, experiment with large language models, centrally manage AI agents and assets, deploy scalable vectorization data pipelines, enable non-developer users to create their own AI agents, control access with role-based access controls, and harness capabilities from Azure AI and Azure OpenAI. The platform simplifies integration with enterprise data sources, provides fine-grain security controls, load balances across multiple endpoints, and is extensible to new data sources and orchestrators. FoundationaLLM addresses the need for customized copilots or AI agents that are secure, licensed, flexible, and suitable for enterprise-scale production.

Obsidian Weaver is a plugin that integrates ChatGPT/GPT-3 into the note-taking workflow of Obsidian. It allows users to easily access AI-generated suggestions and insights within Obsidian, enhancing the writing and brainstorming process. The plugin respects Obsidian's philosophy of storing notes locally, ensuring data security and privacy. Weaver offers features like creating new chat sessions with the AI assistant and receiving instant responses, all within the Obsidian environment. It provides a seamless integration with Obsidian's interface, making the writing process efficient and helping users stay focused. The plugin is constantly being improved with new features and updates to enhance the note-taking experience.

OpenCRISPR is a set of free and open gene editing systems designed by Profluent Bio. The OpenCRISPR-1 protein maintains the prototypical architecture of a Type II Cas9 nuclease but is hundreds of mutations away from SpCas9 or any other known natural CRISPR-associated protein. You can view OpenCRISPR-1 as a drop-in replacement for many protocols that need a cas9-like protein with an NGG PAM and you can even use it with canonical SpCas9 gRNAs. OpenCRISPR-1 can be fused in a deactivated or nickase format for next generation gene editing techniques like base, prime, or epigenome editing.

NoLabs is an open-source biolab that provides easy access to state-of-the-art models for bio research. It supports various tasks, including drug discovery, protein analysis, and small molecule design. NoLabs aims to accelerate bio research by making inference models accessible to everyone.

OpenCRISPR is a set of free and open gene editing systems designed by Profluent Bio. The OpenCRISPR-1 protein maintains the prototypical architecture of a Type II Cas9 nuclease but is hundreds of mutations away from SpCas9 or any other known natural CRISPR-associated protein. You can view OpenCRISPR-1 as a drop-in replacement for many protocols that need a cas9-like protein with an NGG PAM and you can even use it with canonical SpCas9 gRNAs. OpenCRISPR-1 can be fused in a deactivated or nickase format for next generation gene editing techniques like base, prime, or epigenome editing.

The Ersilia Model Hub is a unified platform of pre-trained AI/ML models dedicated to infectious and neglected disease research. It offers an open-source, low-code solution that provides seamless access to AI/ML models for drug discovery. Models housed in the hub come from two sources: published models from literature (with due third-party acknowledgment) and custom models developed by the Ersilia team or contributors.

OntoGPT is a Python package for extracting structured information from text using large language models, instruction prompts, and ontology-based grounding. It provides a command line interface and a minimal web app for easy usage. The tool has been evaluated on test data and is used in related projects like TALISMAN for gene set analysis. OntoGPT enables users to extract information from text by specifying relevant terms and provides the extracted objects as output.

BIA `bob` is a Jupyter-based assistant for interacting with data using large language models to generate Python code. It can utilize OpenAI's chatGPT, Google's Gemini, Helmholtz' blablador, and Ollama. Users need respective accounts to access these services. Bob can assist in code generation, bug fixing, code documentation, GPU-acceleration, and offers a no-code custom Jupyter Kernel. It provides example notebooks for various tasks like bio-image analysis, model selection, and bug fixing. Installation is recommended via conda/mamba environment. Custom endpoints like blablador and ollama can be used. Google Cloud AI API integration is also supported. The tool is extensible for Python libraries to enhance Bob's functionality.

Scientific Large Language Models (Sci-LLMs) is a repository that collects papers on scientific large language models, focusing on biology and chemistry domains. It includes textual, molecular, protein, and genomic languages, as well as multimodal language. The repository covers various large language models for tasks such as molecule property prediction, interaction prediction, protein sequence representation, protein sequence generation/design, DNA-protein interaction prediction, and RNA prediction. It also provides datasets and benchmarks for evaluating these models. The repository aims to facilitate research and development in the field of scientific language modeling.

Polaris establishes a novel, industry‑certified standard to foster the development of impactful methods in AI-based drug discovery. This library is a Python client to interact with the Polaris Hub. It allows you to download Polaris datasets and benchmarks, evaluate a custom method against a Polaris benchmark, and create and upload new datasets and benchmarks.

The 'awesome-AI4MolConformation-MD' repository focuses on protein conformations and molecular dynamics using generative artificial intelligence and deep learning. It provides resources, reviews, datasets, packages, and tools related to AI-driven molecular dynamics simulations. The repository covers a wide range of topics such as neural networks potentials, force fields, AI engines/frameworks, trajectory analysis, visualization tools, and various AI-based models for protein conformational sampling. It serves as a comprehensive guide for researchers and practitioners interested in leveraging AI for studying molecular structures and dynamics.