OpenCRISPR is a set of free and open gene editing systems designed by Profluent Bio. The OpenCRISPR-1 protein maintains the prototypical architecture of a Type II Cas9 nuclease but is hundreds of mutations away from SpCas9 or any other known natural CRISPR-associated protein. You can view OpenCRISPR-1 as a drop-in replacement for many protocols that need a cas9-like protein with an NGG PAM and you can even use it with canonical SpCas9 gRNAs. OpenCRISPR-1 can be fused in a deactivated or nickase format for next generation gene editing techniques like base, prime, or epigenome editing.

AnkiGPT is a tool that leverages GPT-3.5 or GPT-4 by OpenAI to generate flashcards from lecture slides or text input. Users can easily export the generated flashcards to Anki for effective learning. The tool allows users to edit, delete, and share flashcards, as well as generate mnemonics. AnkiGPT supports nearly all languages and ensures user privacy by not using submitted content for AI training. While powerful, the tool has limitations such as occasional errors in generated flashcards and challenges with mathematical equations. AnkiGPT is designed specifically for Anki flashcard app integration and encourages users to review and verify flashcard information for accuracy.

An artificial intelligence framework entirely written in Java for game development with libGDX. It is a high-performance framework providing common AI techniques used in the game industry, covering movement AI, pathfinding, decision making, and infrastructure. The framework is designed to be used with libGDX but can be used independently. Current features include steering behaviors, formation motion, A* pathfinding, hierarchical pathfinding, behavior trees, state machine, message handling, and scheduling.

Clipboard Conqueror is a multi-platform omnipresent copilot alternative. Currently requiring a kobold united or openAI compatible back end, this software brings powerful LLM based tools to any text field, the universal copilot you deserve. It simply works anywhere. No need to sign in, no required key. Provided you are using local AI, CC is a data secure alternative integration provided you trust whatever backend you use. *Special thank you to the creators of KoboldAi, KoboldCPP, llamma, openAi, and the communities that made all this possible to figure out.

FoundationaLLM is a platform designed for deploying, scaling, securing, and governing generative AI in enterprises. It allows users to create AI agents grounded in enterprise data, integrate REST APIs, experiment with large language models, centrally manage AI agents and assets, deploy scalable vectorization data pipelines, enable non-developer users to create their own AI agents, control access with role-based access controls, and harness capabilities from Azure AI and Azure OpenAI. The platform simplifies integration with enterprise data sources, provides fine-grain security controls, load balances across multiple endpoints, and is extensible to new data sources and orchestrators. FoundationaLLM addresses the need for customized copilots or AI agents that are secure, licensed, flexible, and suitable for enterprise-scale production.

Breadboard is a library for prototyping generative AI applications. It is inspired by the hardware maker community and their boundless creativity. Breadboard makes it easy to wire prototypes and share, remix, reuse, and compose them. The library emphasizes ease and flexibility of wiring, as well as modularity and composability.

Greenplum Database (GPDB) is an advanced, fully featured, open source data warehouse, based on PostgreSQL. It provides powerful and rapid analytics on petabyte scale data volumes. Uniquely geared toward big data analytics, Greenplum Database is powered by the world’s most advanced cost-based query optimizer delivering high analytical query performance on large data volumes.

TypeChat is a library that simplifies the creation of natural language interfaces using types. Traditionally, building natural language interfaces has been challenging, often relying on complex decision trees to determine intent and gather necessary inputs for action. Large language models (LLMs) have simplified this process by allowing us to accept natural language input from users and match it to intent. However, this has introduced new challenges, such as the need to constrain the model's response for safety, structure responses from the model for further processing, and ensure the validity of the model's response. Prompt engineering aims to address these issues, but it comes with a steep learning curve and increased fragility as the prompt grows in size.

This repository is a comprehensive guide for individuals looking to start and improve their skills in Large Language Models (LLMs) without an advanced background in the field. It provides free resources, online courses, books, articles, and practical tips to become an expert in machine learning. The guide covers topics such as terminology, transformers, prompting, retrieval augmented generation (RAG), and more. It also includes recommendations for podcasts, YouTube videos, and communities to stay updated with the latest news in AI and LLMs.

Trace is a new AutoDiff-like tool for training AI systems end-to-end with general feedback. It generalizes the back-propagation algorithm by capturing and propagating an AI system's execution trace. Implemented as a PyTorch-like Python library, users can write Python code directly and use Trace primitives to optimize certain parts, similar to training neural networks.

MindWork AI Studio is a desktop application that provides a unified chat interface for Large Language Models (LLMs). It is free to use for personal and commercial purposes, offers independence in choosing LLM providers, provides unrestricted usage through the providers API, and is cost-effective with pay-as-you-go pricing. The app prioritizes privacy, flexibility, minimal storage and memory usage, and low impact on system resources. Users can support the project through monthly contributions or one-time donations, with opportunities for companies to sponsor the project for public relations and marketing benefits. Planned features include support for more LLM providers, system prompts integration, text replacement for privacy, and advanced interactions tailored for various use cases.

Obsidian Weaver is a plugin that integrates ChatGPT/GPT-3 into the note-taking workflow of Obsidian. It allows users to easily access AI-generated suggestions and insights within Obsidian, enhancing the writing and brainstorming process. The plugin respects Obsidian's philosophy of storing notes locally, ensuring data security and privacy. Weaver offers features like creating new chat sessions with the AI assistant and receiving instant responses, all within the Obsidian environment. It provides a seamless integration with Obsidian's interface, making the writing process efficient and helping users stay focused. The plugin is constantly being improved with new features and updates to enhance the note-taking experience.

This repository contains a collection of sample applications and Jupyter Notebooks for hands-on experience with Pinecone vector databases and common AI patterns, tools, and algorithms. It includes production-ready examples for review and support, as well as learning-optimized examples for exploring AI techniques and building applications. Users can contribute, provide feedback, and collaborate to improve the resource.

Tiledesk is an Open Source Live Chat platform with integrated Chatbots written in NodeJs and Express. It provides a multi-channel platform for Web, Android, and iOS, offering out-of-the-box chatbots that work alongside humans. Users can automate conversations using native chatbot technology powered by AI, connect applications via APIs or Webhooks, deploy visual applications within conversations, and enable applications to interact with chatbots or end-users. Tiledesk is multichannel, allowing chatbot scripts with images and buttons to run on various channels like Whatsapp, Facebook Messenger, and Telegram. The project includes Tiledesk Server, Dashboard, Design Studio, Chat21 ionic, Web Widget, Server, Http Server, MongoDB, and a proxy. It offers Helm charts for Kubernetes deployment, but customization is recommended for production environments, such as integrating with external MongoDB or monitoring/logging tools. Enterprise customers can request private Docker images by contacting [email protected].

HybridAGI is the first Programmable LLM-based Autonomous Agent that lets you program its behavior using a **graph-based prompt programming** approach. This state-of-the-art feature allows the AGI to efficiently use any tool while controlling the long-term behavior of the agent. Become the _first Prompt Programmers in history_ ; be a part of the AI revolution one node at a time! **Disclaimer: We are currently in the process of upgrading the codebase to integrate DSPy**

LF AI & Data Landscape is a map to explore open source projects in the AI & Data domains, highlighting companies that are members of LF AI & Data. It showcases members of the Foundation and is modelled after the Cloud Native Computing Foundation landscape. The landscape includes current version, interactive version, new entries, logos, proper SVGs, corrections, external data, best practices badge, non-updated items, license, formats, installation, vulnerability reporting, and adjusting the landscape view.

OpenCRISPR is a set of free and open gene editing systems designed by Profluent Bio. The OpenCRISPR-1 protein maintains the prototypical architecture of a Type II Cas9 nuclease but is hundreds of mutations away from SpCas9 or any other known natural CRISPR-associated protein. You can view OpenCRISPR-1 as a drop-in replacement for many protocols that need a cas9-like protein with an NGG PAM and you can even use it with canonical SpCas9 gRNAs. OpenCRISPR-1 can be fused in a deactivated or nickase format for next generation gene editing techniques like base, prime, or epigenome editing.

NoLabs is an open-source biolab that provides easy access to state-of-the-art models for bio research. It supports various tasks, including drug discovery, protein analysis, and small molecule design. NoLabs aims to accelerate bio research by making inference models accessible to everyone.

OpenCRISPR is a set of free and open gene editing systems designed by Profluent Bio. The OpenCRISPR-1 protein maintains the prototypical architecture of a Type II Cas9 nuclease but is hundreds of mutations away from SpCas9 or any other known natural CRISPR-associated protein. You can view OpenCRISPR-1 as a drop-in replacement for many protocols that need a cas9-like protein with an NGG PAM and you can even use it with canonical SpCas9 gRNAs. OpenCRISPR-1 can be fused in a deactivated or nickase format for next generation gene editing techniques like base, prime, or epigenome editing.

The Ersilia Model Hub is a unified platform of pre-trained AI/ML models dedicated to infectious and neglected disease research. It offers an open-source, low-code solution that provides seamless access to AI/ML models for drug discovery. Models housed in the hub come from two sources: published models from literature (with due third-party acknowledgment) and custom models developed by the Ersilia team or contributors.

OntoGPT is a Python package for extracting structured information from text using large language models, instruction prompts, and ontology-based grounding. It provides a command line interface and a minimal web app for easy usage. The tool has been evaluated on test data and is used in related projects like TALISMAN for gene set analysis. OntoGPT enables users to extract information from text by specifying relevant terms and provides the extracted objects as output.

BIA `bob` is a Jupyter-based assistant for interacting with data using large language models to generate Python code. It can utilize OpenAI's chatGPT, Google's Gemini, Helmholtz' blablador, and Ollama. Users need respective accounts to access these services. Bob can assist in code generation, bug fixing, code documentation, GPU-acceleration, and offers a no-code custom Jupyter Kernel. It provides example notebooks for various tasks like bio-image analysis, model selection, and bug fixing. Installation is recommended via conda/mamba environment. Custom endpoints like blablador and ollama can be used. Google Cloud AI API integration is also supported. The tool is extensible for Python libraries to enhance Bob's functionality.

Scientific Large Language Models (Sci-LLMs) is a repository that collects papers on scientific large language models, focusing on biology and chemistry domains. It includes textual, molecular, protein, and genomic languages, as well as multimodal language. The repository covers various large language models for tasks such as molecule property prediction, interaction prediction, protein sequence representation, protein sequence generation/design, DNA-protein interaction prediction, and RNA prediction. It also provides datasets and benchmarks for evaluating these models. The repository aims to facilitate research and development in the field of scientific language modeling.

Polaris establishes a novel, industry‑certified standard to foster the development of impactful methods in AI-based drug discovery. This library is a Python client to interact with the Polaris Hub. It allows you to download Polaris datasets and benchmarks, evaluate a custom method against a Polaris benchmark, and create and upload new datasets and benchmarks.

The 'awesome-AI4MolConformation-MD' repository focuses on protein conformations and molecular dynamics using generative artificial intelligence and deep learning. It provides resources, reviews, datasets, packages, and tools related to AI-driven molecular dynamics simulations. The repository covers a wide range of topics such as neural networks potentials, force fields, AI engines/frameworks, trajectory analysis, visualization tools, and various AI-based models for protein conformational sampling. It serves as a comprehensive guide for researchers and practitioners interested in leveraging AI for studying molecular structures and dynamics.